Adrenal Diseases

Adrenal Glands

Location of the Adrenal Glands

Adrenal glands, also known as suprarenal glands, are small, triangular-shaped glands located on top of both kidneys.

Adrenal glands produce hormones that help regulate your metabolism, immune system, blood pressure, response to stress and other essential functions.

Adrenal glands are composed of two parts — the cortex and the medulla — which are each responsible for producing different hormones.

When adrenal glands don’t produce enough hormones, this can lead to adrenal insufficiency (Addison’s disease).

Adrenal glands may develop nodules that can be benign or malignant. These nodules may produce excessive amounts of certain hormones leading to various health issues.

Anatomy of the Adrenal Glands

Adrenal Gland Diagram

An adrenal gland is made of two main parts:

The adrenal cortex is the outer region and also the largest part of an adrenal gland. It is divided into three separate zones: zona glomerulosa, zona fasciculata and zona reticularis. Each zone is responsible for producing specific hormones.

The adrenal medulla is located inside the adrenal cortex in the center of an adrenal gland. It produces several “stress hormones,” including adrenaline.

The adrenal cortex and adrenal medulla are enveloped in an adipose capsule that forms a protective layer around an adrenal gland.

Hormones of the Adrenal Glands

The role of the adrenal glands in your body is to release certain hormones directly into the bloodstream. Many of these hormones have to do with how the body responds to stress, and some are vital to existence. Both parts of the adrenal glands — the adrenal cortex and the adrenal medulla — perform distinct and separate functions.

Each zone of the adrenal cortex secretes a specific hormone. The key hormones produced by the adrenal cortex include:


Cortisol is a glucocorticoid hormone produced by the zona fasciculata that plays several important roles in the body. It helps control the body’s use of fats, proteins and carbohydrates; suppresses inflammation; regulates blood pressure; increases blood sugar; and can also decrease bone formation.

This hormone also controls the sleep/wake cycle. It is released during times of stress to help your body get an energy boost and better handle an emergency situation.

How Adrenal Glands Work to Produce Cortisol

Adrenal glands produce hormones in response to signals from the hypothalamus and the pituitary gland in the brain. For example, for the adrenal gland to produce cortisol:

The hypothalamus produces corticotropin-releasing hormone (CRH) that stimulates the pituitary gland to secrete adrenocorticotropin hormone (ACTH).

The ACTH then stimulates the adrenal glands to make and release cortisol hormones into the blood.

Normally, both the hypothalamus and the pituitary gland can sense whether the blood has the right amount of cortisol in it. If there is too much or too little cortisol, these glands respectively change the amount of CRH and ACTH that gets released.

Excess cortisol production can occur from nodules in the adrenal gland or excess production of ACTH from a tumor in the pituitary gland or other source.


This mineralocorticoid hormone produced by the zona glomerulosa plays a central role in regulating blood pressure and certain electrolytes (sodium and potassium). Aldosterone sends signals to the kidneys, resulting in the kidneys absorbing more sodium into the bloodstream and releasing potassium into the urine. This means that aldosterone also helps regulate the blood pH by controlling the levels of electrolytes in the blood.

DHEA and Androgenic Steroids

These hormones produced by the zona reticularis are weak male hormones. They are precursor hormones that are converted in the ovaries into female hormones (estrogens) and in the testes into male hormones (androgens). However, estrogens and androgens are produced in much larger amounts by the ovaries and testes.

Epinephrine (Adrenaline) and Norepinephrine (Noradrenaline)

The adrenal medulla, the inner part of an adrenal gland, controls hormones that help you cope with physical and emotional stress. The main hormones secreted by the adrenal medulla include epinephrine (adrenaline) and norepinephrine (noradrenaline), which have similar functions.

Among other things, these hormones are capable of increasing the heart rate and force of heart contractions, increasing blood flow to the muscles and brain, relaxing smooth muscles, and assisting in sugar metabolism. They also control the squeezing of the blood vessels (vasoconstriction), helping maintain blood pressure and increasing it in response to stress.

Like several other hormones produced by the adrenal glands, epinephrine and norepinephrine are often activated in stressful situations when your body needs additional resources and energy to endure unusual strain.

Adrenal Gland Disorders

The two common ways in which adrenal glands cause health issues are by producing too little or too much of certain hormones, which leads to hormonal imbalances. These abnormalities of the adrenal function can be caused by various diseases of the adrenal glands or the pituitary gland.

Adrenal Insufficiency

Adrenal insufficiency is a rare disorder. It may be caused by disease of the adrenal glands (primary adrenal insufficiency, Addison’s disease) or by diseases in the hypothalamus or the pituitary (secondary adrenal insufficiency). It is the opposite of Cushing syndrome and is characterized by low levels of cortisol (and aldosterone in the primary form). The symptoms include weight loss, poor appetite, nausea and vomiting, fatigue, darkening of skin (only in primary adrenal insufficiency), abdominal pain, etc.

The causes of primary adrenal insufficiency may include autoimmune disorders, fungal and other infections, cancer (rarely), and genetic factors.

Although adrenal insufficiency usually develops over time, it can also appear suddenly as an acute adrenal failure (adrenal crisis). It has similar symptoms, but the consequences are more serious, including coma, shock and seizures. These may develop if the condition is left untreated.

Congenital Adrenal Hyperplasia

Adrenal insufficiency can also result from a genetic disorder called congenital adrenal hyperplasia. Children who are born with this disorder are missing an essential enzyme necessary to produce cortisol, aldosterone or both. At the same time, they often experience excess of androgen, which may lead to male characteristics in girls and precocious puberty in boys.

Congenital adrenal hyperplasia can remain undiagnosed for years depending on the severity of the enzyme deficiency. In more severe cases, infants may suffer from dehydration, vomiting and failure to thrive.

Overactive Adrenal Glands

Sometimes, adrenal glands may develop nodules that produce too much of certain hormones. Nodules 4 centimeters or larger and nodules that show certain features on imaging may be cancerous. Both benign and cancerous nodules may produce excessive amounts of certain hormones, which often is referred to as an overactive adrenal gland.

Excess of Cortisol: Cushing Syndrome

Cushing syndrome results from excessive production of cortisol from the adrenal glands. The symptoms may include weight gain and fatty deposits in certain areas of the body, such as the face, below the back of the neck and in the abdomen; thinning arms and legs; purple stretch marks on the abdomen; facial hair; fatigue; muscle weakness; easily bruised skin; high blood pressure; diabetes; and other health issues.

Excess cortisol production can also be triggered by overproduction of ACTH by a benign tumor in the pituitary gland. This is known as Cushing Disease. Another common cause of Cushing syndrome is excessive and prolonged consumption of external steroids, such as prednisone or dexamethasone, which are prescribed to treat many autoimmune or inflammatory diseases (e.g., lupus, rheumatoid arthritis, asthma, inflammatory bowel disease, multiple sclerosis, etc.)

Excess of Aldosterone: Hyperaldosteronism

Hyperaldosteronism results from overproduction of aldosterone from one or both adrenal glands. This is characterized by increase in blood pressure that often requires many medications to control. Some people can develop low potassium levels in the blood, which can cause muscle aches, weakness and spasms. When the cause is a benign tumor in one adrenal gland, the disease is called Conn syndrome.

Excess of Adrenaline or Noradrenaline: Pheochromocytoma

Pheochromocytoma is a tumor that results in excess production of adrenaline or noradrenaline by the adrenal medulla that often happens in bursts. Occasionally, neural crest tissue, which is similar to the adrenal medulla, may be the cause of overproduction of these hormones. This condition is called a paraganglioma.

Pheochromocytomas may cause persistent or sporadic high blood pressure that may be difficult to control with regular medications. Other symptoms include headaches, sweating, tremors, anxiety and rapid heartbeat. Some people are genetically predisposed to developing this type of tumor.

Adrenal Cancer

Malignant adrenal tumors (adrenal cancer), such as adrenocortical carcinoma, are rare and often have spread to other organs and tissues by the time they are diagnosed. These tumors tend to grow fairly large and can reach several inches in diameter.

Adrenal cancer may cause adrenal glands to produce excess of one or more hormones accompanied by corresponding symptoms, as listed above. You may also experience abdominal pain or flank pain and a feeling of fullness if the adrenal tumor gets very large.

Not all cancers found in adrenal glands start there. Most adrenal cancers are secondary cancers that start elsewhere in the body and spread to the adrenal glands.